| Lhermitte's Sign | Electric shock sensation on neck flexion | Multiple Sclerosis |
| Uhthoff's Phenomenon | Symptom worsening with heat | Multiple Sclerosis |
| Marcus Gunn Pupil | Pupil dilates when light is swung to affected eye | Optic neuritis |
| Dawson's Fingers | Periventricular demyelinating lesions on MRI | Multiple Sclerosis |
| Internuclear Ophthalmoplegia | Impaired adduction with nystagmus in opposite eye | MS, brainstem lesions |
| Charcot's Triad (MS) | Nystagmus, intention tremor, scanning speech | Multiple Sclerosis |
| Cogwheel Rigidity | Ratchet-like resistance to passive movement | Parkinson's Disease |
| Lead-pipe Rigidity | Uniform resistance throughout movement | Parkinsonism |
| Myerson's Sign | Persistent blinking when glabella tapped | Parkinson's Disease |
| Pill-rolling Tremor | Resting tremor of thumb and forefinger | Parkinson's Disease |
| Festinating Gait | Short, accelerating steps | Parkinson's Disease |
| Chorea | Involuntary, irregular, purposeless movements | Huntington's Disease |
| Hemiballismus | Violent flinging movements of limbs | Subthalamic nucleus lesion |
| Dystonia | Sustained muscle contractions causing abnormal posture | Primary or secondary dystonias |
| Athetosis | Slow, writhing movements | Cerebral palsy, basal ganglia lesions |
| Kernig's Sign | Pain/resistance on knee extension with hip flexed | Meningitis |
| Brudzinski's Sign | Neck flexion causes hip/knee flexion | Meningitis |
| Neck Stiffness | Resistance to passive neck flexion | Meningitis |
| Jolt Accentuation | Headache worsens with horizontal head rotation | Meningitis |
| Fatigable Ptosis | Eyelid drooping worsens with sustained upgaze | Myasthenia Gravis |
| Cogan's Lid Twitch | Upper lid overshoots after downgaze | Myasthenia Gravis |
| Peek Sign | Eyelids slowly separate with sustained closure | Myasthenia Gravis |
| Ice Pack Test | Improvement in ptosis after ice application | Myasthenia Gravis |
| Babinski Sign | Upgoing big toe with plantar stimulation | UMN Lesion |
| Hoffmann's Sign | Flicking middle finger causes thumb flexion | Cervical myelopathy |
| Clasp-knife Spasticity | Initial resistance followed by sudden release | UMN Lesion |
| Pronator Drift | Arm pronates and drifts downward | UMN Lesion |
| Fasciculations | Visible muscle twitches | LMN Lesion, MND |
| Flaccid Paralysis | Loss of tone and reflexes | LMN Lesion |
| Atrophy | Muscle wasting | LMN Lesion |
| Bells Phenomenon | Upward eye roll on eyelid closure attempt | Facial Nerve Palsy |
| Argyll Robertson Pupil | Pupil accommodates but no light reflex | Neurosyphilis |
| Relative Afferent Pupillary Defect | Pupil paradoxically dilates with light in affected eye | Optic nerve lesion |
| Jaw Jerk Reflex | Exaggerated in UMN lesions above pons | Pseudobulbar palsy |
| Brown-Séquard Syndrome | Hemisection with ipsilateral motor loss | Spinal injury |
| Clonus | Rhythmic contractions on sudden stretch | Spinal cord lesion |
| Spinal Shock | Temporary loss of reflexes below lesion | Acute spinal injury |
| Romberg's Sign | Unsteadiness with eyes closed | Posterior column lesion |
| Lhermitte's Phenomenon | Electric shock with neck flexion | Cervical cord lesion |
| Stocking-Glove Loss | Distal sensory loss | Peripheral neuropathy |
| Allodynia | Pain from non-painful stimuli | Neuropathic pain |
| Froment's Sign | Thumb IP flexion when gripping paper | Ulnar nerve palsy |
| Battle's Sign | Mastoid bruising | Basilar skull fracture |
| Raccoon Eyes | Periorbital ecchymosis | Basilar skull fracture |
| Gowers' Sign | Climbing up thighs to stand | Duchenne muscular dystrophy |
| Tinel's Sign | Tingling on tapping nerve | Carpal tunnel syndrome |
| Phalen's Maneuver | Wrist flexion reproduces symptoms | Carpal tunnel syndrome |
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