Lathyrism
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Lathyrism – Quick Revision Chart
| Aspect | Details |
|---|---|
| Cause | Prolonged consumption of Lathyrus sativus (Khesari dal / Grass pea) |
| Toxic Agent | BOAA (β-N-oxalyl-amino-L-alanine) – a neurotoxic amino acid |
| Epidemiology | Common in drought/famine-hit areas of India (MP, Bihar, Chhattisgarh, UP, Odisha) |
| Types of Lathyrism | 1. Neurolathyrism – Spastic paraparesis 2. Osteolathyrism – Skeletal deformities 3. Angiolathyrism – Aneurysms due to collagen/elastin defect |
| Organs/System Affected | Nervous system, Bones, Blood vessels |
| Early Symptoms | Stiffness and weakness in legs, especially after exertion |
| Late Symptoms | Spastic gait, paralysis of lower limbs, disability |
| Mode of Action | BOAA damages upper motor neurons |
| High Risk Groups | Poor, rural populations relying on Khesari dal as staple diet |
| Prevention | Dietary diversification, Soaking/boiling seeds, Ban on cultivation/sale, Nutrition education |
| Government Measures | Banned sale of Khesari dal in many states (still grown as cattle fodder in some areas) |
Key Facts 🔑
- Lathyrism is a preventable neurotoxic disease.
- Caused by prolonged consumption of grass pea.
- Early dietary intervention prevents disability.
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